Pharmacokinetic Difference of Six Active Constituents of Huangqi Liuyi Decoction between Control and Diabetic Nephropathy Mouse Models

Table 6

The pharmacokinetic parameters of astragaloside IV after HQD administration.

Pharmacokinetic parameter	Unit	Astragaloside IV
		Control group	Model group
T1/2	h	9.85 ± 0.82	15.11 ± 1.15
Tmax	h	1.75 ± 0.29	2.75 ± 0.50
Cmax	ng/mL	1248 ± 101.7	1882 ± 429.1
AUC(0–t)	ngh/mL	7624 ± 235.7	14414 ± 952.1
AUC(0–∞)	ngh/mL	8012 ± 266.8	15710 ± 895.4
VZ/F	mL/kg	191756 ± 1417	15025 ± 1133
CLZ/F	mL/h/kg	1351 ± 44.04	690.3 ± 39.31
MRT(0–t)	h	9.95 ± 0.47	10.49 ± 1.13
MRT(0–∞)	h	12.44 ± 1.19	15.33 ± 1.60

ps: vs. control group, ^∗P < 0.05, ^∗∗P < 0.01.