Pharmacokinetic Difference of Six Active Constituents of Huangqi Liuyi Decoction between Control and Diabetic Nephropathy Mouse Models

Table 7

The pharmacokinetic parameters of glycyrrhizic acid after HQD administration ( ± SD, n = 8).

Pharmacokinetic parameter	Unit	Glycyrrhizic acid
		Control group	Model group
T1/2	h	9.87 ± 1.64	17.78 ± 3.55
Tmax	h	1.38 ± 0.25	1.63 ± 0.25
Cmax	ng/mL	1892 ± 513.8	2661 ± 630.1
AUC(0–t)	ngh/mL	6962 ± 729.8	12174 ± 1374
AUC(0–∞)	ngh/mL	7152 ± 725.4	13725 ± 1497
VZ/F	mL/kg	180200 ± 40486	169076 ± 38405
CLZ/F	mL/h/kg	12618 ± 1340	6590 ± 787.4
MRT(0–t)	h	9.12 ± 0.96	11.48 ± 1.71
MRT(0–∞)	h	10.56 ± 0.45	18.49 ± 4.74

ps: vs. control group, ^∗P < 0.05, ^∗∗P < 0.01.