Pharmacokinetic Difference of Six Active Constituents of Huangqi Liuyi Decoction between Control and Diabetic Nephropathy Mouse Models

Table 8

The pharmacokinetic parameters of calycosin-7-O-β-D-glucoside after HQD administration ( ± SD, n = 8).

Pharmacokinetic parameter	Unit	Calycosin-7-O-β-D-glucoside
		Control group	Model group
T1/2	h	3.22 ± 0.88	3.85 ± 2.21
Tmax	h	1.13 ± 0.25	1.25 ± 0.29
Cmax	ng/mL	117.5 ± 34.19	161.2 ± 39.84
AUC(0–t)	ngh/mL	118.3 ± 12.90	191.0 ± 15.68
AUC(0–∞)	ngh/mL	175.7 ± 22.75	273.9 ± 49.48
VZ/F	mL/kg	65898 ± 12674	48618 ± 20157
CLZ/F	mL/h/kg	14611 ± 2106	9473 ± 1511
MRT(0–t)	h	1.62 ± 0.21	1.37 ± 0.11
MRT(0–∞)	h	4.27 ± 1.44	4.30 ± 1.90

ps: vs. control group, ^∗P < 0.05, ^∗∗P < 0.01.