Pharmacokinetic Difference of Six Active Constituents of Huangqi Liuyi Decoction between Control and Diabetic Nephropathy Mouse Models

Table 9

The pharmacokinetic parameters of calycosin-glucuronide after HQD administration ( ± SD, n = 8).

Pharmacokinetic parameter	Unit	Calycosin-glucoside
		Control group	Model group
T1/2	h	13.16 ± 1.74	15.62 ± 1.50
Tmax	h	0.88 ± 0.25	1.13 ± 0.25
Cmax	ng/mL	704.6 ± 152.8	954.8 ± 194.7
AUC(0–t)	ngh/mL	1851 ± 264.6	2701 ± 211.0
AUC(0–∞)	ngh/mL	2034 ± 265.9	2977 ± 218.1
VZ/F	mL/kg	21128 ± 4333	16877 ± 1939
CLZ/F	mL/h/kg	1110 ± 144.3	749.9 ± 55.07
MRT(0–t)	h	10.15 ± 0.32	10.47 ± 0.44
MRT(0–∞)	h	15.27 ± 1.08	15.98 ± 1.87

ps: vs. control group, ^∗P < 0.05, ^∗∗P < 0.01.