A Validated RP-HPLC Method for Simultaneous Determination of Cefixime and Clavulanic Acid Powder in Pediatric Oral Suspension

Table 11

Solutions stability data of the proposed HPLC method for cefixime.

Parameter	Stability conditions	RT	Avg. peak area	%RSD (peak area)	Tailing factor	Assay (%)	%RSD (assay)	Number of theoretical plates
Standard solution	0 h	7.68	1102.022	0.1573	1.065	—	—	2566.332
	After 24 h at 30°C	7.19	1103.382	0.0854	1.134	—	—	2553.285
	After 24 h at the refrigerator	7.30	1159.015	0.0246	1.10	—	—	2556.207
Sample solution	0 h	7.52	1108.138	0.3846	1.11	98.85	0.3721	2382.315
	After 24 h at 30°C	7.37	1108.723	0.0506	1.16	98.74	0.1475	2370.762
	After 24 h at the refrigerator	7.43	1167.680	0.0506	1.10	99.04	0.1610	2438.755