A Validated RP-HPLC Method for Simultaneous Determination of Cefixime and Clavulanic Acid Powder in Pediatric Oral Suspension

Table 12

Solutions stability data of the proposed HPLC method for clavulanic acid.

Parameter	Stability conditions	RT	Avg. peak area	%RSD (peak area)	Tailing factor	Assay (%)	%RSD (assay)	Number of theoretical plates
Standard solution	0 h	3.28	531.098	0.9661	1.459	—	—	5065.394
	After 24 h at 30°C	3.24	517.890	0.3458	1.504	—	—	4948.156
	After 24 h at the refrigerator	3.24	558.564	0.5773	1.516	—	—	4868.868
Sample solution	0 h	3.27	596.532	0.3130	1.467	99.52	0.4378	5080.242
	After 24 h at 30°C	3.25	580.709	0.2932	1.511	99.35	0.3840	4918.414
	After 24 h at the refrigerator	3.25	635.529	0.4743	1.504	100.81	0.5608	4806.592