A Validated RP-HPLC Method for Simultaneous Determination of Cefixime and Clavulanic Acid Powder in Pediatric Oral Suspension

Table 8

Results of repeatability and intermediate precision.

No. of sample solutions	Sample weight (g)	Content of cefixime in oral powder (%, compared to labeled claim)	Content of clavulanic acid in oral powder (%, compared to labeled claim)
Day 1, analyst 1
1	5.5100	99.00	100.43
2	5.5012	99.01	100.16
3	5.5006	99.11	100.33
4	5.5123	98.88	99.68
5	5.5198	98.82	99.61
6	5.5118	98.98	98.92
Average (1–6)		98.97	100.02
%RSD (1–6)		0.1051	0.3402
Day 2, analyst 1
7	5.5100	98.60	99.85
8	5.5012	99.40	99.41
9	5.5006	98.39	99.47
10	5.5123	99.82	99.48
11	5.5198	99.35	99.15
12	5.5118	98.94	98.44
Average (7–12)		99.08	99.47
%RSD (7–12)		0.5437	0.2232
Day 2, analyst 2
13	5.5088	98.71	100.15
14	5.5069	99.08	99.48
15	5.5006	98.83	99.41
16	5.5108	99.37	99.52
17	5.5029	99.48	99.39
18	5.5105	98.04	99.21
Average (13–18)		98.92	99.53
%RSD (13–18)		0.3806	0.3259