Research Article
Determination of Scopolamine Distribution in Plasma and Brain by LC-MS/MS in Rats
| Sample | Nominal conc. (ng/mL) | Intraday batch | Interday batch | Accuracy (%, RE) | Precision (%, RSD) | Accuracy (%, RE) | Precision (%, RSD) |
| Plasma | 2 | 111.36 | 4.75 | 118.89 | 1.03 | 5 | 98.78 | 7.61 | 110.50 | 1.18 | 250 | 112.16 | 12.94 | 112.46 | 12.38 | 1875 | 103.25 | 14.12 | 107.27 | 11.06 |
| Brain homogenate | 2 | 109.92 | 4.84 | 87.72 | 3.98 | 5 | 97.33 | 10.74 | 107.32 | 1.57 | 250 | 114.35 | 14.60 | 109.96 | 4.04 | 1875 | 93.23 | 2.58 | 94.10 | 10.65 |
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