Determination of Scopolamine Distribution in Plasma and Brain by LC-MS/MS in Rats

Table 4

Matrix effect and recovery.

Sample	Nominal conc. (ng/mL)	Matrix effect (%)		Recovery (%)
		(Mean ± SD), n = 6	RSD	(Mean ± SD), n = 6	RSD
Plasma	5	96.12 ± 5.56	5.79	185.99 ± 25.52	13.72
	1875	87.13 ± 3.65	4.09	142.81 ± 14.08	9.86
Brain homogenate	5	114.01 ± 13.00	11.40	155.04 ± 20.73	13.37
	1875	99.81 ± 6.79	6.81	92.87 ± 5.65	6.08