Research Article
Determination of Scopolamine Distribution in Plasma and Brain by LC-MS/MS in Rats
| Sample | Nominal conc. (ng/mL) | Refrigerated for 24 h (4°C) | Refrigerated for 48 h (4°C) | Accuracy (%, RE) | Precision (%, RSD) | Accuracy (%, RE) | Precision (%, RSD) |
| Plasma | 5 | 106.72 | 3.81 | 109.36 | 5.32 | 1875 | 108.41 | 2.53 | 114.18 | 8.61 |
| Brain homogenate | 5 | 93.93 | 4.05 | 106.84 | 4.78 | 1875 | 111.58 | 1.58 | 91.25 | 11.20 |
|
|