Research Article
Determination of Scopolamine Distribution in Plasma and Brain by LC-MS/MS in Rats
Table 6
Repeated freeze-thaw and autosampler stability.
| | Sample | Nominal conc. (ng/mL) | One freeze-thaw cycle | Two freeze-thaw cycles | Autosampler (12 h) | | Accuracy (%, RE) | Precision (%, RSD) | Accuracy (%, RE) | Precision (%, RSD) | Accuracy (%, RE) | Precision (%, RSD) |
| | Plasma | 5 | 109.45 | 3.21 | 143.99 | 9.45 | 87.22 | 7.88 | | 1875 | 97.46 | 2.21 | 114.27 | 3.93 | 99.73 | 9.82 |
| | Brain homogenate | 5 | 115.70 | 9.44 | 106.54 | 1.07 | 117.94 | 4.33 | | 1875 | 91.09 | 3.01 | 86.23 | 6.35 | 113.22 | 3.25 |
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