Integrated Serum Metabolomics and Network Pharmacology to Reveal the Interventional Effects of Quzhi Decoction against Osteoarthritis Pain

Figure 4

The identification of different metabolites after Quzhi decoction treatment in KOA rats. (a) Total ion chromatogram (TIC) of the methanol extract acquired by GS-MS; (b) PLSDA of metabolites in the KOA rats. Each point in the figure represents a sample, and all the sample points are distributed in the circular region. N = 8; (c) heatmap of identified differential metabolites among the sham, KOA and KOA + Quzhi groups; (d) bubble chart of metabolic pathways from significant metabolites. Node size is based on impact values, and node color is based on −log10 () values.

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