Comparative Pharmacokinetic Study of 5 Active Ingredients after Oral Administration of Zuogui Pill in Osteoporotic Rats with Different Syndrome Types

Table 4

Accuracy and precision of 5 analytes in rat plasma (n = 6).

Analytes	Concentration (ng/mL)	Accuracy (%)		Precision (%)
		Intra-day	Inter-day	Intra-day	Inter-day
Chlorogenic acid	1	18.6	18.0	12.4	9.5
	2	12.1	14.3	10.0	6.1
	40	10.2	11.0	10.3	7.6
	800	6.7	8.1	3.9	8.2
Loganin	20	17.4	14.2	10.6	13.7
	40	13.8	12.1	7.1	10.9
	800	7.5	5.6	6.4	5.8
	16000	2.3	2.5	3.9	4.1
Morroniside	4	13.3	16.6	10.6	12.0
	8	11.1	9.4	8.7	8.7
	160	6.6	9.2	7.3	2.9
	3200	3.4	8.6	5.9	3.1
Aucubin	0.5	13.0	14.7	10.4	10.5
	1	12.5	9.0	7.5	8.0
	20	3.7	7.1	5.8	5.3
	400	4.0	5.3	3.7	4.9
Protocatechuic aldehyde	0.05	11.4	14.6	10.2	13.8
	0.1	8.0	13.2	9.6	9.1
	2	7.7	13.2	7.4	8.4
	40	6.2	8.8	4.4	4.9