Research Article
Comparative Pharmacokinetic Study of 5 Active Ingredients after Oral Administration of Zuogui Pill in Osteoporotic Rats with Different Syndrome Types
Table 5
Recover and matrix effect of 5 analytes in rat plasma (n = 6).
| | Analytes | Concentration (ng/mL) | Recovery (%) | Matrix effect (%) | | Mean | RSD | Mean | RSD |
| | Chlorogenic acid | 2 | 65.0 | 8.5 | 85.3 | 6.1 | | 40 | 88.2 | 4.6 | 90.7 | 4.4 | | 800 | 78.0 | 10.3 | 86.8 | 4.7 |
| | Loganin | 40 | 81.3 | 3.3 | 76.3 | 14.9 | | 800 | 87.6 | 9.7 | 93.7 | 5.9 | | 16000 | 91.9 | 7.0 | 86.5 | 3.7 |
| | Morroniside | 8 | 80.3 | 1.8 | 92.0 | 8.3 | | 160 | 82.2 | 6.6 | 76.7 | 5.4 | | 3200 | 84.1 | 10.7 | 85.5 | 1.9 |
| | Aucubin | 1 | 76.7 | 4.3 | 80.7 | 6.1 | | 20 | 77.7 | 3.3 | 94.4 | 14.4 | | 400 | 88.0 | 2.6 | 91.8 | 8.9 |
| | Protocatechuic aldehyde | 0.1 | 85.4 | 2.7 | 81.5 | 6.1 | | 2 | 85.8 | 9.6 | 79.4 | 6.0 | | 40 | 85.9 | 8.9 | 91.5 | 4.5 |
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