Comparative Pharmacokinetic Study of 5 Active Ingredients after Oral Administration of Zuogui Pill in Osteoporotic Rats with Different Syndrome Types

Table 6

Stability of 5 analytes in rat plasma under various conditions (n = 5).

Analytes	Concentration (ng/mL)	Room temperature for 4 h (%)		Autosampler at 4°C for 24 h (%)		Three freeze-thaw cycles (%)
		Mean	RSD	Mean	RSD	Mean	RSD
Chlorogenic acid	2	86.5	6.0	85.1	4.6	89.1	5.1
	40	85.9	2.2	93.7	3.8	89.3	7.7
	800	85.7	4.2	87.3	6.2	80.9	10.9
Loganin	40	88.3	9.5	94.6	5.1	86.4	12.4
	800	87.4	6.1	85.8	7.0	89.5	6.9
	16000	85.6	11.3	84.4	3.9	92.4	3.3
Morroniside	8	90.8	9.1	89.6	5.8	93.0	2.7
	160	86.1	7.5	87.6	4.6	91.5	6.3
	3200	98.3	3.4	95.0	2.1	89.8	7.7
Aucubin	1	89.8	2.8	88.6	4.7	84.2	9.0
	20	91.3	8.0	92.5	7.4	86.9	8.3
	400	92.8	6.6	90.2	5.8	89.1	6.1
Protocatechuic aldehyde	0.1	86.8	2.5	88.4	8.9	90.8	6.5
	2	90.9	3.3	89.3	6.5	83.4	5.7
	40	87.4	6.0	85.9	3.1	89.5	4.4