Comparative Pharmacokinetic Study of 5 Active Ingredients after Oral Administration of Zuogui Pill in Osteoporotic Rats with Different Syndrome Types
Table 7
Pharmacokinetic parameters of the 5 compounds in rats after oral administration of Zuogui Pill extract and integrated pharmacokinetic parameters (n = 6).
Compounds
Groups
t1/2(h)
Tmax(h)
Cmax(ng/mL)
AUC0–t(hng/mL)
AUC0–∞(hng/mL)
CL_F_obs (mL/h/kg)
MRT0–t(h)
MRT0–∞(h)
Chlorogenic acid
Normal
8.17 ± 1.79
0.25 ± 0.00
346.14 ± 63.99
497.98 ± 34.72
546.26 ± 38.80
914.49 ± 64.88
5.46 ± 0.48
8.17 ± 1.46
Osteoporosis
6.38 ± 1.96
0.26 ± 0.02
279.27 ± 56.34
435.76 ± 59.78
489.67 ± 77.69
1036.09 ± 154.41
6.78 ± 0.68
9.72 ± 2.61
Yang-deficiency
5.41 ± 1.84
0.25 ± 0.00
430.29 ± 98.55
263.13 ± 40.25
284.31 ± 33.34
1767.90 ± 187.68
4.52 ± 1.46
6.56 ± 2.64
Yin-deficiency
6.61 ± 3.84
0.25 ± 0.00
353.83 ± 83.80
218.55 ± 23.29
225.89 ± 25.03
2223.36 ± 229.72
3.03 ± 0.38
4.10 ± 1.02
Loganin
Normal
4.51 ± 0.45
0.25 ± 0.00
13508.61 ± 2029.85
20134.29 ± 3958.79
20523.97 ± 3947.05
361.54 ± 73.02
4.58 ± 0.47
5.10 ± 0.41
Osteoporosis
2.74 ± 0.96
0.25 ± 0.00
8381.77 ± 1123.47
17912.12 ± 6898.16
17998.56 ± 6945.75
460.13 ± 196.92
4.91 ± 1.29
5.02 ± 1.34
Yang-deficiency
5.62 ± 1.63
0.21 ± 0.05
14.72 ± 1.38
27.46 ± 4.83
28.61 ± 4.91
257023.69 ± 42243.40
5.50 ± 0.67
6.62 ± 0.49
Yin-deficiency
3.75 ± 0.70
0.25 ± 0.00
16025.83 ± 2787.58
41028.61 ± 6356.26
41727.10 ± 6203.34
176.22 ± 32.93
6.51 ± 0.91
6.92 ± 0.98
Morroniside
Normal
3.66 ± 1.18
0.29 ± 0.10
1719.66 ± 410.02
2151.00 ± 498.88
2171.33 ± 509.45
2966.14 ± 684.64
3.41 ± 0.33
3.66 ± 0.48
Osteoporosis
2.40 ± 0.51
0.26 ± 0.02
1109.11 ± 163.31
1724.77 ± 149.05
1741.55 ± 136.08
3553.71 ± 268.04
4.37 ± 0.43
4.51 ± 0.38
Yang-deficiency
3.83 ± 0.64
0.19 ± 0.04
1450.08 ± 337.06
1726.42 ± 217.11
1750.35 ± 215.20
3562.14 ± 427.53
4.68 ± 0.24
5.03 ± 0.33
Yin-deficiency
2.90 ± 0.65
0.24 ± 0.03
1752.12 ± 321.11
3764.53 ± 842.38
3782.41 ± 832.52
1700.88 ± 406.17
5.08 ± 0.74
5.21 ± 0.78
Aucubin
Normal
5.97 ± 2.89
0.38 ± 0.14
84.43 ± 32.22
170.50 ± 64.82
204.69 ± 68.61
1358.04 ± 638.52
5.38 ± 2.01
8.58 ± 2.71
Osteoporosis
3.67 ± 0.78
0.17 ± 0.00
102.55 ± 23.62
116.40 ± 11.00
155.64 ± 24.54
1592.72 ± 276.68
3.06 ± 0.12
5.62 ± 1.09
Yang-deficiency
7.40 ± 1.68
0.25 ± 0.00
95.99 ± 24.19
48.33 ± 14.05
111.33 ± 29.94
2328.79 ± 701.23
2.95 ± 0.38
11.69 ± 1.31
Yin-deficiency
8.68 ± 2.92
0.25 ± 0.00
181.24 ± 30.66
201.40 ± 32.43
272.67 ± 70.63
959.16 ± 279.31
7.32 ± 1.92
14.14 ± 5.85
Protocatechuic aldehyde
Normal
10.87 ± 4.48
0.45 ± 0.10
18.86 ± 3.62
64.15 ± 10.30
119.88 ± 32.93
750.08 ± 184.83
5.14 ± 0.17
15.85 ± 6.12
Osteoporosis
12.01 ± 4.69
0.30 ± 0.00
10.10 ± 1.99
34.92 ± 2.37
72.28 ± 21.64
1279.06 ± 400.34
5.52 ± 0.21
17.76 ± 6.26
Yang-deficiency
2.09 ± 0.89
0.25 ± 0.07
11.38 ± 1.31
24.70 ± 1.69
28.68 ± 6.49
3031.25 ± 535.72
2.55 ± 0.18
3.50 ± 1.38
Yin-deficiency
2.20 ± 0.83
0.17 ± 0.07
8.81 ± 1.61
27.48 ± 3.10
28.87 ± 2.69
2933.07 ± 265.58
3.24 ± 0.37
3.79 ± 0.79
Integrated
Normal
4.51 ± 0.44
0.25 ± 0.00
11927.33 ± 1782.67
17749.62 ± 3510.27
18091.33 ± 3477.17
390.40 ± 78.84
4.57 ± 0.47
5.09 ± 0.40
Osteoporosis
2.74 ± 0.95
0.25 ± 0.00
7474.98 ± 1002.61
16439.99 ± 6012.37
16516.89 ± 6056.71
472.07 ± 192.41
4.77 ± 1.27
4.87 ± 1.32
Yang-deficiency
3.91 ± 0.65
0.19 ± 0.04
1210.34 ± 269.75
1486.54 ± 179.09
1507.82 ± 177.63
3452.60 ± 389.82
4.51 ± 0.23
4.87 ± 0.33
Yin-deficiency
3.79 ± 0.64
0.25 ± 0.00
14669.30 ± 2504.17
38171.03 ± 5606.50
38810.41 ± 5480.02
184.70 ± 32.39
6.39 ± 0.89
6.80 ± 0.94
and , according to a one-way ANOVA, versus osteoporosis rats.
