Determination of Tenacissoside G, Tenacissoside H, and Tenacissoside I in Rat Plasma by UPLC-MS/MS and Their Pharmacokinetics

Table 2

Stability of tenacissoside G, tenacissoside H, and tenacissoside I in rat plasma.

Compound	Concentration (ng/mL)	Autosampler (4°C, 12 h)		Ambient (2 h)		−20°C (30 d)		Freeze-thaw
		Accuracy	RSD	Accuracy	RSD	Accuracy	RSD	Accuracy	RSD
Tenacissoside G	8	102.1	11.3	104.9	12.9	106.8	12.9	100.0	9.1
	180	97.8	6.7	95.0	4.9	99.9	1.4	111.3	11.5
	1800	100.2	2.2	100.1	8.9	93.4	5.7	88.7	12.3
Tenacissoside H	8	102.6	9.5	102.3	7.8	102.2	12.3	94.8	10.9
	180	101.5	4.7	95.5	11.8	88.2	3.6	110.9	14.5
	1800	95.9	7.5	102.2	7.9	109.6	3.9	94.2	7.1
Tenacissoside I	8	94.8	5.1	105.5	10.9	90.4	14.3	88.0	8.9
	180	103.0	4.5	95.3	5.0	103.1	11.2	109.2	13.0
	1800	102.2	8.5	99.2	8.9	106.6	2.8	102.8	13.4