Determination of Tenacissoside G, Tenacissoside H, and Tenacissoside I in Rat Plasma by UPLC-MS/MS and Their Pharmacokinetics

Table 3

Main pharmacokinetic parameters after intravenous (IV, 1 mg/kg) and oral (PO, 5 mg/kg) administration of tenacissoside G, tenacissoside H, and tenacissoside I in rats.

Compound	Group	AUC(0-t) (ng/mL·h)	AUC(0-∞) (ng/mL·h)	t1/2z (h)	CLz/F (L/h/kg)	Vz/F (L/kg)	Cmax (ng/mL)
Tenacissoside G	po	2037.0 ± 630.4	2046.0 ± 639.2	0.9 ± 0.3	2.7 ± 0.9	3.6 ± 1.6	900.2 ± 246.3
	iv	1778.5 ± 419.6	1801.4 ± 418.2	0.8 ± 0.3	0.6 ± 0.2	0.7 ± 0.3	1137.1 ± 386.1
Tenacissoside H	po	1336.5 ± 146.1	1359.8 ± 127.7	1.8 ± 0.6	10.1 ± 4.0	325.5 ± 18.2	1336.5 ± 146.1
	iv	361.2 ± 35.7	364.6 ± 36.5	1.3 ± 0.1	5.0 ± 0.5	303.7 ± 30.9	361.2 ± 35.7
Tenacissoside I	po	113.0 ± 8.5	116.9 ± 9.9	1.1 ± 0.3	43.0 ± 3.8	69.6 ± 16.0	60.3 ± 7.7
	iv	239.5 ± 28.9	240.3 ± 28.8	0.7 ± 0.1	4.2 ± 0.6	4.3 ± 0.8	225.8 ± 52.4