Discrimination of Traditional Chinese Medicine Syndromes in Type 2 Diabetic Patients Based on Metabolomics-Proteomics Profiles

Figure 1

The analysis of functional enrichment of the differentially abundant proteins in T2DM patients with/without damp-heat syndrome (DHS). (a) The volcano map exhibited differentially abundant proteins (DHS vs. non-DHS group). Remarkably differentially abundant proteins were coded by color: red and blue represent increased and decreased proteins, respectively. Two clusters composed of twelve decreased and three increased proteins. (b) Radar chart analysis for group DHS vs. non-DHS. The conversion value of log2 was utilized as a baseline, and the corresponding quantitative value ratio of differential protein was calculated. The black number in the figure indicated the fold change. (c) The bubble chart reflected the classification outcomes of the top 15 most remarkable enrichment, containing molecular function, the cellular component, and the biological process (). In bubble chart, the vertical axis represented the pathway or functional classification, and the horizontal axis represented the enrichment factor, which represented the comparison between the proportional value of identified proteins and the proportional value of differentially rich proteins in the functional type. The color of circle showed the enrichment value, and the size of circle reflected the differentially abundant protein number in pathways or functional categories.

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