Liquid Chromatography-Tandem Mass Spectrometry Detection of Human and Veterinary Drugs and Pesticides in Surface Water

Table 1

Instrument conditions for human and veterinary drugs and pesticide residues analysis.

Ionization modes		ESI+							ESI−
LC condition	Mobile phase	A	0.1% formic acid in water						A	0.1% ammonia in water
		B	Acetonitrile						B	Acetonitrile
	Gradient list	Time (min)	0	8	10	14	14.1	17	Time (min)	0	3	7	7.1	8
		A (%)	90	75	40	40	90	90	A (%)	90	10	10	90	90
		B (%)	10	25	60	60	10	10	B (%)	10	90	90	10	10
	Total flow (mL min^−1)	0.5							0.5
	Column	Sigma-Aldrich C18 column							Thermo Betasil C18 column
		(100 mm × 4.6 mm, 3 μm)							(100 mm × 2.1 mm, 5 μm)
	Column temperature (°C)	40							40
MS condition	Ion source gas1 (psi)	40							40
	Ion source gas2 (psi)	40							40
	Curtain gas (psi)	30							30
	Collision gas (psi)	7							7
	Temperature (°C)	450							450
	Ionspray voltage (V)	5000							−4500