Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons

Table 2

Hazard ratios and 95% CIs for all-cause mortality according to %dSUA quintiles stratified by gender.

Baseline characteristics	%dSUA quintiles			for trend
	Hazard ratio (95% CI)
	Quintile 1	Quintiles 2–4	Quintile 5
	<−1.88% (year)	−1.87 to 2.50% (year)	≥2.51% (year)
Gender
Men N = 543	N = 114	N = 343	N = 86
Prevalence, N (%)	11 (9.6)	30 (8.7)	4 (4.7)
Nonadjusted	3.62 (1.76–7.43)	1.00	1.15 (0.40–3.27)	0.002
Multivariable-adjusted^§	3.79 (1.67–8.48)	1.00	0.87 (0.29–2.61)	0.005
Women N = 758	N = 147	N = 436	N = 175
Prevalence, N (%)	8 (5.4)	20 (4.6)	6 (3.4)
Nonadjusted	5.29 (2.16–13.0)	1.00	1.26 (0.51–3.15)	≤0.001
Multivariable-adjusted^§	4.00 (1.43–11.2)	1.00	1.19 (0.46–3.05)	0.028
Total N = 1,301	N = 261	N = 779	N = 261
Prevalence, N (%)	19 (7.3)	50 (6.4)	10 (3.8)
Nonadjusted	4.45 (2.53–7.82)	1.00	1.08 (0.54–2.13)	<0.001
Multivariable-adjusted^§	3.50 (1.87–6.55)	1.00	0.94 (0.47–1.91)	<0.001

%dSUA, percentage change in serum uric acid; CI, confidence interval. Multivariable-adjusted for gender, age, body mass index, smoking habits, drinking habits, history of cardiovascular disease, hypertension, hypertriglyceridemia, low HDL-cholesterolemia, hyper LDL-cholesterolemia, diabetes, chronic kidney disease, hyperuricemia. Bolded numbers indicate significance ().