Correlation between SMADs and Colorectal Cancer Expression, Prognosis, and Immune Infiltrates

Figure 8

R language was used to analyse the correlation between the differentially expressed SMADs and immune cell infiltration. The expression of (a) SMAD1, (d) SMAD4, and (g) SMAD7 was positively correlated with the infiltration of B cells, CD8+ T cells, dendritic cells, eosinophils, macrophages, and neutrophils. (b) SMAD2 was positively correlated with the infiltration of CD8+ T cells, macrophages, and neutrophils. (c) SMAD3 was positively correlated with the infiltration of B cells, CD8+ T cells, eosinophils, and macrophages. (e) SMAD5 was negatively correlated with dendritic cells and positively correlated with macrophages. (f) SMAD6 was positively correlated with dendritic cells and negatively correlated with CD8+ T cells, macrophages, and neutrophils. (h) SMAD9 was positively correlated with eosinophils and negatively correlated with neutrophils.

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