Research Article
Correlation between SMADs and Colorectal Cancer Expression, Prognosis, and Immune Infiltrates
Table 1
Correlation between immune cell infiltration and SMADs in CRC.
| Genes | Spearman | Cells | B cells | CD8+ T cells | DC | Eosinophils | Macrophages | Neutrophils |
| SMAD1 | r | 0.230 | 0.190 | 0.160 | 0.190 | 0.280 | 0.220 | p | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
| SMAD2 | r | 0.049 | 0.210 | 0.037 | 0.037 | 0.290 | 0.130 | p | 0.217 | <0.001 | 0.347 | 0.352 | <0.001 | 0.001 |
| SMAD3 | r | 0.085 | 0.120 | 0.054 | 0.200 | 0.086 | 0.046 | p | 0.030 | 0.002 | 0.170 | <0.001 | 0.029 | 0.246 |
| SMAD4 | r | 0.130 | 0.230 | 0.130 | 0.084 | 0.340 | 0.220 | p | 0.001 | <0.001 | 0.001 | 0.032 | <0.001 | <0.001 |
| SMAD5 | r | −0.062 | 0.050 | −0.150 | −0.041 | 0.110 | −0.031 | p | 0.116 | 0.205 | <0.001 | 0.297 | 0.005 | 0.436 |
| SMAD6 | r | 0.004 | −0.097 | 0.089 | 0.032 | −0.310 | −0.170 | p | 0.910 | 0.014 | 0.024 | 0.417 | <0.001 | <0.001 |
| SMAD7 | r | 0.260 | 0.170 | 0.160 | 0.260 | 0.130 | 0.078 | p | <0.001 | <0.001 | <0.001 | <0.001 | 0.001 | 0.048 |
| SMAD9 | r | 0.047 | 0.009 | 0.071 | 0.100 | −0.033 | −0.110 | p | 0.234 | 0.816 | 0.072 | 0.010 | 0.396 | 0.007 |
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