Research Article

Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS

Table 2

Main pharmacokinetic parameters after intragastric (5 mg/kg) and intravenous (1 mg/kg) administration of ziyuglycoside I and ziyuglycoside II in rats.

CompoundGroupAUC(0-t)AUC(0-∞)CLz/F
ng/mL  hng/mL  hhL/h/kgL/kgng/mL

Ziyuglycoside Iig95.4 ± 7.2109.0 ± 11.85.1 ± 2.546.3 ± 5.2329.2 ± 143.636.6 ± 5.8
iv834.7 ± 249.2838.3 ± 250.31.8 ± 0.71.3 ± 0.33.5 ± 2.01268.0 ± 344.8

Ziyuglycoside IIig438.9 ± 42.4458.3 ± 46.34.9 ± 1.511.0 ± 1.077.3 ± 22.5102.2 ± 14.5
iv1933.2 ± 209.11979.2 ± 185.76.2 ± 3.10.54.6 ± 2.41374.3 ± 224.5