The Chick as a Model for the Study of the Cellular Mechanisms and Potential Therapies for Alzheimer's Disease

Table 3

Summary of peptides and their effects on memory reported in this study.

Peptide	Injection route		Effective dose		Rescue of amnesia induced with:			Enhances weak training	Crossing BBB	𝑡1/2  hour
	Ic	ip	Ic 𝜇g/brain	Ip mg/kg bw	Anti APP	AS	A𝛽			Up to
RERMS	Y	Y	4	20–25	Y	Y	Y	Y	Y	2
SMRER	Y	Y	4	20–25	Y	Y	Y	Y	Y	2
RSAER	N	N	4	/	N	N	N	N	Y	/
RER	Y	Y	4	20–25	Y	Y	Y	Y	Y	/
Ac-RER	Y	Y	16	20–25	Y	/	Y	Y	Y	6
Ac-RRE	N	N	16	/	/	/	N	N	/	/
Ac-rER	Y	Y	16	20–25	Y	/	Y	Y	Y	>12
Ac-REr	N	N	16	/	N	/	N	N	/	/
Ac-ReR	N	N	16	/	N	/	N	N	/	/
Ac-rer	Y	Y	16	20–25	N	/	N	N	/	/

Y: yes, there is an effect on memory; N: No, there is no effect on memory; Anti-APP: monoclonal antibody, clone mAb22C11 [17]; AS: 16-mer end-protected phosphodiester oligodeoxynucleotide, 5^′ CXC GAG GAC TGA XCC A 3^′, designed to correspond to the transcription start sites −146 and AUG1786 of the 𝛽APP mRNA, immediately upstream of a ribozyme binding site [17]; A𝛽: amyloid-beta. For further details see [18, 49, 50].