Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, <i>C. Pneumoniae</i>, Other Suspect Pathogens, and the Immune System

<table>Portions of the complement cascade in relation to beta-amyloid processing: Alzheimer’s disease susceptibility genes returned from very large genomewide association studies are in black, and those from the pre-GWAS era in grey. Binding interactions are indicated by linked diamonds and other effects by arrows. C. Neo: <i>Cryptococcus neoformans</i>; C. Pneu: <i>chlamydia pneumoniae</i>; H. Pyl: <i>Helicobacter pylori</i>; P. Ging: <i>Porphyromonas gingivalis</i>; C1–C9: complement components. MAC: membrane attack complex. P-choline: phosphatidylcholine; black star: Herpes simplex: see text for details.</table>

International Journal of Alzheimer’s Disease

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Figure 2

Figure 2: Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, <i>C. Pneumoniae</i>, Other Suspect Pathogens, and the Immune System 

Figure 2 | Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System 