Correlation of Copper Interaction, Copper-Driven Aggregation, and Copper-Driven H₂O₂ Formation with Aβ40 Conformation

Figure 3

EPR spectra for Cu²⁺ only, Aβ40/Cu²⁺ in either 5% or 40% TFE. The characteristic g_‖ and g_⟂ hyperfine peaks appeared in 5% and 40% TFE represent that copper ion coordinates with Aβ40 in a 3N1O mode. The characteristic bands in 40% TFE are slightly shift downfield compared with the hyperfine peaks appeared in 5% TFE, suggesting that Aβ40 adopts different conformation in 5% and 40% TFE.