Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease

Figure 2

Chemical structures of ThT (thioflavin-T), a neutral ThT derivative, Pittsburgh Compound B, the KLVFF peptide, curcumin, IMPY, and p-I-stilbene (ThT = 2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium; neutral ThT derivative = 2-(4-(dimethylamino)phenyl)-6-methylbenzothiazole; Pittsburgh Compound B = 2-[4-(methyl-¹¹C-amino)phenyl]-6-benzothiazolol; curcumin = ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; IMPY = 4-(7-iodoimidazo[1,2-a]pyridin-2-yl)-N,N-dimethylaniline; p-I-stilbene = N,N-dimethyl-4-[(1E)-2-(4-iodophenyl)ethenyl]benzenamine).