The Pathogenesis of Alzheimer's Disease: A Reevaluation of the “Amyloid Cascade Hypothesis”

<table>A modification of the Amyloid Cascade Hypothesis (ACH). A<i>β</i>: <i>β</i>-amyloid, APOE: apolipoprotein E, APP: amyloid precursor protein, <i>PSEN1/2</i>: <i>presenilin  genes  1  and  2</i>, NFTs: neurofibrillary tangles, and SPs: senile plaques.</table>

International Journal of Alzheimer’s Disease

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Figure 3

Figure 3: The Pathogenesis of Alzheimer's Disease: A Reevaluation of the “Amyloid Cascade Hypothesis” 