Resting-State Glucose Metabolism Level Is Associated with the Regional Pattern of Amyloid Pathology in Alzheimer's Disease
Figure 4
The relationship between resting glucose metabolism levels and PIB uptakes. The correlation between regional resting glucose metabolism in normal elderly subjects and regional PIB uptake in Alzheimer’s disease (AD) patients from various different brain areas is highly significant (0.788, ). This correlation demonstrates that brain regions with high resting glucose metabolism in normal elderly subjects have high PIB uptakes in AD patients and that brain regions with low resting glucose metabolism have low PIB uptakes in AD patients. Most importantly, it should be noted that resting glucose metabolism level and PIB uptake are correlated not only in the brain’s default network regions but also in brain regions outside the default network.
