Resting-State Glucose Metabolism Level Is Associated with the Regional Pattern of Amyloid Pathology in Alzheimer's Disease
Table 2
2-[18F]fluoro-2-deoxy-D-glucose (FDG) and [11C]-labeled Pittsburgh Compound B (PIB) uptakes in the default network regions and regions outside the default network in Alzheimer’s disease (AD) and control subjects.
Subject
Control
AD
Radiotracer
FDG
PIB
FDG
PIB
Default network
MFG
1.20 ± 0.074
1.09 ± 0.104
0.96 ± 0.137††
1.92 ± 0.229**
MTC
0.81 ± 0.041
1.06 ± 0.084
0.74 ± 0.069†
1.16 ± 0.126*
LTC
0.98 ± 0.033
1.11 ± 0.099
0.83 ± 0.120†
1.63 ± 0.207**
IP
1.11 ± 0.045
1.09 ± 0.078
0.90 ± 0.123††
1.84 ± 0.164**
PCC
1.21 ± 0.039
1.10 ± 0.090
1.00 ± 0.158†
2.11 ± 0.198**
PFC
1.11 ± 0.042
1.08 ± 0.152
0.93 ± 0.115†
1.88 ± 0.183**
OFC
1.10 ± 0.043
1.02 ± 0.163
0.92 ± 0.123†
1.74 ± 0.161**
HIP
0.82 ± 0.052
1.03 ± 0.082
0.76 ± 0.109
1.03 ± 0.116
Nondefault network
PU
1.21 ± 0.080
1.21 ± 0.194
1.16 ± 0.118
2.05 ± 0.350**
STG
1.04 ± 0.042
1.13 ± 0.090
0.89 ± 0.135†
1.57 ± 0.216*
TH
1.19 ± 0.090
1.29 ± 0.109
1.08 ± 0.115†
1.44 ± 0.250
VC
1.24 ± 0.050
1.05 ± 0.117
1.28 ± 0.131
1.46 ± 0.250**
OC
1.13 ± 0.048
1.09 ± 0.098
1.12 ± 0.119
1.57 ± 0.220*
AMY
0.72 ± 0.050
1.00 ± 0.096
0.69 ± 0.062
1.06 ± 0.109
Mean ± SD. versus FDG control, two-tailed t test. †† versus FDG control.
*
versus PIB control, two-tailed t test.
**
versus. PIB control. MFG: middle frontal gyrus, MTC: medial temporal cortex, LTC: lateral temporal cortex, IP: inferior parietal lobe, PCC: posterior cingulate cortex, PFC: prefrontal cortex, OFC: orbitofrontal cortex, HIP: hippocampus, PU: putamen, STG: superior temporal gyrus, TH: thalamus, VC: visual cortex, OC: occipital cortex, AMY: amygdala.
