Florbetaben PET in the Early Diagnosis of Alzheimer's Disease: A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps

Table 4

Cost inputs.

Cost item	Value	Unit	Data source
Diagnostic work-up
AD+	$5,120	Per year
VaD	$5,885	Per year	VA VISN 1 and [16–18]
Other non-AD	$6,638	Per year
Predementia	$6,187	Per year
Imaging and biomarker tests
MRI + MTA	$437	Per test
CT + MTA	$300	Per test
FDG-PET	$1,042	Per test	[16], manufacturer
SPECT	$596	Per test
CSF	$304	Per test
Florbetaben PET	$2,300	Per test
Dementia medication
Donepezil	$7.79	Per day
Galantamine	$6.36	Per day	[19]
Rivastigmine	$6.11	Per day
Memantine	$7.89	Per day
Medical care for predementia	$5,548	Per year	[20]
Medical care for AD+
Mild	$8,315	Per year
Mildly moderate	$12,806	Per year
Moderate	$12,806	Per year	[20]
Moderately severe	$18,526	Per year
Severe	$23,227	Per year
Nonmedical care for AD+
Mild	$154	Per year
Mildly moderate	$3,692	Per year
Moderate	$12,166	Per year	[20]
Moderately severe	$14,209	Per year
Severe	$23,355	Per year
% of additional cost of care for non-AD relative to AD
VaD	84%		[21]
Other non-AD	37%
Institutional care	$373	Per day	[22]
Caregiver time	$7.25	Per hour	[23]
Caregiver burden for predementia	2.10	Hours per day	[20]
Caregiver burden for dementia
Mild	2.10	Hours per day
Mildly moderate	3.58	Hours per day
Moderate	3.58	Hours per day	[20]
Moderately severe	3.76	Hours per day
Severe	5.10	Hours per day

AD: Alzheimer’s disease; VaD: vascular dementia; MRI: magnetic resonance imaging; MTA: medial temporal lobe atrophy; CT: computer tomography; PET: positron emission tomography; FDG: fluorodeoxyglucose; SPECT: single photon emission computer tomography; CSF: cerebral spinal fluid.