Research Article
Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology
Table 6
Disease association of the pairs of low TO gene modules in Soler-López et al.'s AD PPI network.
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Number of low TO genes with high connectivity in regional coexpression network number of low TO genes with higher connectivity in one brain region + number of low TO genes with equal connectivity in both brain regions. There are 1704 proteins in ADnet. In EC HIP, 204 low TO genes ADnet 15 proteins. In EC MTG, 140 low TO genes ADnet 21 proteins. In EC PCC, 242 low TO genes ADnet 23 proteins. In HIP MTG, 125 low TO genes ADnet 12 proteins. In HIP PCC, 312 low TO genes ADnet 27 proteins. In PCC MTG, 158 low TO genes ADnet 16 proteins. Disease annotation cluster analysis was conducted on pairs of exclusive low TO modules (pairs of low TO modules excluding common proteins between module pairs). MTG seems to be least associated with cardiovascular diseases (CVD). When comparing EC and HIP, EC is highly associated with CVD. When comparing EC and PCC, PCC is highly associated with CVD. When comparing HIP and PCC, PCC is highly associated with CVD. |