Novel Biomarkers for Alzheimer’s Disease: Plasma Neurofilament Light and Cerebrospinal Fluid

Table 1

Molecules that showed differential levels in CSF from Alzheimer’s disease patients as compared to controls.

Protein	Up/downregulated
Albumin	↑
Amyloid β A4 protein	↑
Apolipoprotein AI	↑
Apolipoprotein AII	↑
Apolipoprotein E	↑
BACE 1	↑
24S-Hydroxycholesterol	↑
C3a	↑
C4a	↑
Cystatin C	↑
Cystatin C, 8 amino acid N-terminal truncation	↑
Immunoglobulin heavy chain	↓
Leucine-rich repeat-containing protein 4B	↑
Leucine-rich repeat-containing protein 4B	↓
N-acetyllactosamine	↓
Neuronal pentraxin-1	↑
Prostaglandin-H2 D-isomerase	↑; ↓
Retinol-binding protein	↑
Thioredoxin	↑
Transthyretin	↓; ↑; ↓
VGF	↑
a-1-Antitrypsin	↑
α-1β glycoprotein	↑
α-2HS glycoprotein	↓
β fibrinogen	↑
β-2-Microglobulin	↓