17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats
Figure 4
% Tumor cells positive for ERα and PARP. Seven-week-old female Lewis rats were treated with a single IP injection of 50 mg/kg MNU. Tumors developed for 90 days, prior to treatment () for 14 days with cyclodextrin vehicle daily, or 6.6 mg HE3235 daily. Paraffin sections of tumors were examined for histopathology and stained for immunohistochemistry with antibodies to PARP or ER. HE3235 treatment increased the frequency of cells staining positive for the apoptotic maker, PARP, and decreased the frequency of ERα, which is associated with tumor survival. *.
