MRP8/ABCC11 Expression Is Regulated by Dexamethasone in Breast Cancer Cells and Is Associated to Progesterone Receptor Status in Breast Tumors

Figure 2

Alterations of ABCC11 mRNA and protein level by DEX and PROG. (a) Cells were exposed to either 5 μM DEX or 15 μM PROG for 72 h. Fold change of mRNA levels of ABCC11 was determined by QRT-PCR. The QRT-PCR values indicated below are means ± S.D. of 4 independent experiments; 𝑦 is a logarithmic scale. *𝑃<.05; student’s 𝑡-test. (b) Crude membrane fractions (150 μg) were prepared from cells exposed to either vehicle, 5 μM DEX or 15 μM PROG for 72 h.

(a)

(b)