MRP8/ABCC11 Expression Is Regulated by Dexamethasone in Breast Cancer Cells and Is Associated to Progesterone Receptor Status in Breast Tumors

Table 1

Relationships between ABCC11 mRNA expression, PR-status and ER-status in breast tumors from postmenopausal patients.

	Subgroup	𝑛	Median	Range; (min-max)	Ratio; (subgroup 2 median/subgroup 1 median)	𝑃^‡
Present study^†§	PR−	26	2,22	(0,1–289)	5,79	.014
	PR+	34	12,86	(0,6–354)
	ER−/PR−	23	1,50	(0,1–177)	11,21	.009
	ER−/PR+	12	16,82	(0,8–354)
	ER+/PR−	3	33,37	(8,9–289)	0,36	.181
	ER+/PR+	22	11,99	(0,6–286)
Bittner's study	PR−	116	86,50	(2,4–12494)	2,47	.003
	PR+	129	213,50	(1,7–11933)
	ER−/PR−	83	53,80	(2,4–12494)	9,80	.075
	ER−/PR+	3	527,10	(199,8–1866)
	ER+/PR−	33	225,10	(4,6–4950)	0,87	.871
	ER+/PR+	125	196,00	(1,7–11933)

Present study: 𝑛=60 tumors.
Bittner's study: 𝑛=245; from normalized data published on GEO website GSE2109-ABCC11 (224146_s_at).
^†ABCC11 QRT-PCR expression levels.
^§PR and ER status were measured at the protein level by binding assay.
^‡𝑃-values were considered to be statistically significant if 𝑃<.05 (Mann Whitney's test).