Similarity of Fibroglandular Breast Tissue Content Measured from Magnetic Resonance and Mammographic Images and by a Mathematical Algorithm
Table 4
Multivariate analysis model estimates for percent breast density (%-G), fibroglandular tissue volume (GV), fat tissue volume (FV), and total breast volume (TV) measured by five different methods ().
Explanatory variable
Standardized -estimates (SE)
%-G
GV
FV
TV
BMI
−0.59 (0.09)***
−0.10 (0.11)
0.65 (0.07)***
0.52 (0.08)***
Age
−0.09 (0.07)
−0.13 (0.08)
−0.09 (0.05)
−0.12 (0.06)*
Age at menarche
0.13 (0.07)
0.13 (0.08)
−0.05 (0.05)
0.01 (0.06)
Pregnancy, completed
Zero
Reference
One
0.22 (0.26)
−0.29 (0.32)
−0.28 (0.21)
−0.34 (0.23)
Two
−0.52 (0.21)*
−0.81 (0.27)**
−0.08 (0.17)
−0.34 (0.19)
Three and more
−0.52 (0.22)*
−0.99 (0.28)***
−0.18 (0.18)
−0.49 (0.20)**
Alkaline phosphatase (ALP)
−0.06 (0.08)
0.06 (0.10)
0.12 (0.06)*
0.12 (0.07)
Alanine aminotransferase (ALT)
−0.22 (0.10)*
−0.16 (0.12)
0.07 (0.08)
0.01 (0.09)
Aspartate aminotransferase (AST)
0.32 (0.10)***
0.24 (0.12)*
−0.15 (0.08)
−0.04 (0.09)
Insulin-like growth factor I (IGF-I)
−0.03 (0.07)
−0.10 (0.09)
−0.04 (0.06)
−0.07 (0.06)
Insulin-like growth factor II (IGF-II)
−0.10 (0.07)
0.03 (0.09)
0.16 (0.06)**
0.15 (0.06)*
Sex hormone binding globulin (SHBG)
0.07 (0.07)
−0.09 (0.09)
−0.05 (0.06)
−0.07 (0.06)
C-reactive protein (CRP)
0.13 (0.09)
0.23 (0.11)*
0.05 (0.07)
0.13 (0.08)
17β-Estradiol
−0.09 (0.07)
0.01 (0.09)
0.02 (0.06)
0.02 (0.06)
Progesterone
0.13 (0.07)*
0.20 (0.08)*
−0.02 (0.05)
0.05 (0.06)
Measurement methods#
Histogram segmentation method (HSM)
Reference
Full field digital mammography (FFDM)
−0.02 (0.27)
−0.12 (0.33)
−0.10 (0.21)
0 (0.23)
Mathematical algorithm (MATH)
0.10 (0.27)
0.01 (0.33)
−0.01 (0.21)
0 (0.23)
3D gradient-echo MRI (3DGRE)
−0.04 (0.27)
−0.13 (0.34)
−0.01 (0.21)
−0.10 (0.24)
Short tau inversion recovery MRI (STIR)
−0.10 (0.27)
−0.14 (0.33)
−0.003 (0.21)
−0.09 (0.23)
Race and ethnicity
Non-Hispanic White
Reference
Hispanic
0.30 (0.16)
0.32 (0.20)
−0.11 (0.13)
0.02 (0.14)
African-American
0.40 (0.20)*
0.34 (0.25)
−0.07 (0.16)
0.06 (0.18)
Model
0.54
0.29
0.71
0.65
, , and for predictor strength within a regression model.
#All values >0.05 for interaction terms between predictor variables and measurement methods (results not shown).
