Impact of Undetected Comorbidity on Treatment and Outcomes of Breast Cancer

Table 2

Risk of undetected comorbidity.

	OR	95% CI		𝑃 value
		Lower	Upper
Age at cancer diagnosis (years)
66–70	Reference category
71–75	1.12	1.02	1.22	0.02
76–80	1.28	1.17	1.39	<0.0001
>80	1.53	1.41	1.66	<0.0001
Race/ethnicity
White	Reference category
Black	1.04	0.94	1.16	0.41
Hispanic	0.94	0.81	1.08	0.39
Other	0.83	0.71	0.97	0.02
Year of cancer diagnosis
2001	Reference category
2002	0.99	0.91	1.07	0.75
2003	0.98	0.90	1.07	0.68
2004	0.93	0.85	1.01	0.08
2005	0.92	0.84	1.00	0.05
Index of prior comorbidity score (NCI Comorbidity Index)
0	Reference category
1	1.20	1.13	1.28	<0.0001
≥2	1.50	1.38	1.63	<0.0001
Indicators of poor performance
0	Reference category
≥1	1.30	1.21	1.40	<0.0001
Stage at diagnosis
𝐼𝑛  𝑠𝑖𝑡𝑢	Reference category
I	1.66	1.49	1.85	<0.0001
II	2.40	2.15	2.67	<0.0001
III	3.26	2.87	3.71	<0.0001
IV	5.51	4.85	6.26	<0.0001
Histological grade
Well differentiated	Reference category
Moderately differentiated	1.11	1.02	1.20	0.01
Poorly differentiated	1.15	1.05	1.26	<0.01
Undifferentiated/anaplastic	1.25	1.05	1.50	0.01
Missing/unknown	1.14	1.03	1.27	0.01
Estrogen (ER) and progesterone (PR) receptor status
ER and PR negative	Reference category
ER or PR positive	1.05	0.94	1.16	0.39
ER and PR positive	1.00	0.92	1.09	1.00
Unknown/missing	1.14	1.03	1.27	0.01
Percent in census tract with some college
<25%	Reference category
≥25%	0.99	0.93	1.05	0.70
Percent in census tract living in poverty
<5%	Reference category
5–7%	1.07	0.98	1.17	0.12
8–12%	1.17	1.08	1.27	<0.0001
>12%	1.34	1.25	1.45	<0.0001
Type of geographic area
Large metropolitan	Reference category
Metropolitan	0.97	0.91	1.04	0.42
Urban	1.14	1.02	1.28	0.02
Less urban/rural	1.09	0.99	1.20	0.08

OR: Odds Ratio; CI: Confidence Interval.