Cryo-Imaging and Software Platform for Analysis of Molecular MR Imaging of Micrometastases

Algorithm 1

Pseudocode to find optimal parameters for cost function using lungs.

Input volumes: MRI Volume (after rigid and affine), cryo Volume

Segment Lungs in both the cryo and MRI volumes

for BE = 0 : 0.005 : 0.1

 for JL = 0 : 0.005 : 0.1

  Perform whole mouse deformable registration using as the cost function

  Extract the deformation field for the above transform

  Apply the transform on segmented MRI lungs

  Save the deformed lungs as a binary volume

  Evaluate the volume similarity between the deformed MRI lungs and the reference

cryo lungs

 end

end