Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments

Table 3

Parameters of animal health evaluation.

Parameter	Description
Hair appearance	Texture, color, fall
Skin appearance	Redness, dryness, exudation
Eyes and mucous membranes	Redness, dryness, abnormal secretion
Ataxia	Loss of balance, erratic walk
Paralysis	Loss of response in any limb
Reaction to stimuli	Response to touch or noise
Peripheral vasoconstriction	Pallor
Peripheral vasodilation	Redness
Piloerection	Stiff hair
Salivation	Excess of buccal secretion
Motor activity	Increase or decrease in normal activity, reflect or not
Tremors and convulsions	Spontaneous abnormal muscle contraction, contraction or uncontrolled muscular stretching
Breathing	Increase or decrease in respiratory rate
Dehydration	Robin’s test: pinching the skin, without returning to its normal position
Diarrhea	Soft stools or watery stool
Lose	Weight lose