Preclinical Testing of New Hydrogel Materials for Cartilage Repair: Overcoming Fixation Issues in a Large Animal Model

Figure 4

Histological evaluation of the defects 4 weeks after implantation into trochlea and condylar defects. Collagen type II staining of nonreinforced constructs. Toluidine blue staining of PMMA embedded PCL containing defects. In all osteochondral defects, regardless of PCL-reinforcement, osteolysis of the subchondral bone was found. : bone lysis. Scale bar: 500 μm.