Effect of Formaldehyde and Curcumin on Histomorphological Indices, Gene Expression Associated with Ovarian Follicular Development, and Total Antioxidant to Oxidant Levels in Wistar Rats

Table 2

Comparison of relative gene expression profiles among study groups.

Variables	Formaldehyde^a	Formaldehyde + curcumin^b	Sham^c	Control^d	value
FSHR	1.29 ± 0.45	1.14 ± 0.31	1.28 ± 0.81	1.02 ± 0.15	0.64
GDF-9	1.3 ± 0.42	1.03 ± 0.14	0.99 ± 0.5	1.01 ± 0.52	0.84
KL	3.05 ± 0.75	2.4 ± 0.85	0.87 ± 0.22	0.81 ± 0.33	0.06; 0.6^a,b; 0.03^a,c; 0.03^a,d; 0.19^b,c; 0.34^b,d; 0.9^c,d
FIGLA	0.91 ± 0.36	1.44 ± 0.45	3.07 ± 0.34	3.59 ± 0.55	0.006; 0.44^a,b; 0.009^a,c; 0.02^a,d; 0.02^b,c; 0.01^b,d; 0.99^c,d
BAX	1.18 ± 0.35	1.15 ± 0.24	0.74 ± 0.11	1.1 ± 0.33	0.58
BCL-2	0.99 ± 0.26	1.01 ± 0.2	2.94 ± 0.74	2.94 ± 0.42	0.007; 0.91^a,b; 0.03^a,c; 0.02^a,d; 0.01^b,c; 0.09^b,d; 0.73^c,d
BAX/BCL-2	1.14	1.03	1.11	1.00	—

FSHR: follicle-stimulating hormone receptor, GDF-9: growth differentiation factor-9, FIGLA: factor in germ line alpha, Kl: klotho, BCL-2: B-cell lymphoma 2, and BAX: BCL-2-like protein 4. The data were shown as the mean ± SEM. The Mann–Whitney and Kruskal–Wallis tests were carried out, respectively, to compare two and all groups. SEM: standard error of mean. P < 0.05 was considered as bold values.