Effect of Formaldehyde and Curcumin on Histomorphological Indices, Gene Expression Associated with Ovarian Follicular Development, and Total Antioxidant to Oxidant Levels in Wistar Rats

Table 4

Comparison of oxidant and antioxidant status among study groups.

Variables	Formaldehyde^a	Formaldehyde + curcumin^b	Sham^c	Control^d	value
TOS (μmol/L)	1.49 ± 0.35	1.54 ± 0.37	2.08 ± 0.24	2.18 ± 0.2	>0.05
GPx (mU/ml)	0.005 ± 0.002	0.003 ± 0.0007	0.004 ± 0.0006	0.002 ± 0.0004	0.006; 0.06^a,b; 0.62^b,d; 0.45^b,c; 0.005^a,d; 0.59^a,c; 0.06^c,d
TAC (mmol Fe^2+/L)	1.33 ± 0.3	1.08 ± 0.16	0.93 ± 0.04	0.99 ± 0.03	>0.05
TAC/TOS	1.01	1.93	1.04	1.001	—

TOS: total oxidant status, GPx: glutathione peroxidase activity, and TAC: total antioxidant capacity. The data were presented as the mean ± SD. The one-way ANOVA test was used to compare all the groups, and the post hoc (Tukey) test was performed to compare two groups. SD: standard deviation. P < 0.05 was considered as bold values.