Review Article
The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence
Table 1
Summary of the differences between PRP and PRF [
45,
53].
| PDBs | Platelet-rich plasma (PRP) | Platelet-rich fibrin (PRF) |
| Type of additive in the blood sample | Anticoagulant (bovine thrombin/calcium chloride) | None | Fibrin polymerization rate | Rapid (dependent upon the amount of anticoagulant) | Gradual (natural polymerization in the glass/blood contact area) | Quality of the fibrin network | Rigid network (condensed tetra-molecular/bilateral junctions due to high anticoagulant content) | Flexible network (trimolecular or equilateral junctions) | Effect of fibrin network on cell migration and cytokine release | Unfavorable (due to network rigidity) | Favorable (due to network flexibility) | Modulus of elasticity of the fibrin network | High (due to network rigidity) | Low (due to network flexibility) |
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