The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo
Figure 1
Asymmetric cellular division and signaling in the C. elegans germinal stem cell niche. (a) C. elegans is composed of a distal tip cell (blue), which maintains a niche for the germline stem cells (dark purple) and differentiated germ cells (pink). (b) Binding of Lag-2, which is expressed on the distal tip cell, to the Glp-1 receptor (expressed on the germline stem cell) leads to mitosis. If Lag-2 does not bind to Glp-1, Gld-1 accumulates in the cell, favoring meiosis.
