Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer

<div>Effects of various sizes of HA on stimulating stem cell marker (Nanog, Oct4, Sox2, and KLF-4) expression in <svg height="12.9392pt" id="M26" style="vertical-align:-0.2033005pt" version="1.1" viewbox="0 -12.7359 123.065 12.9392" width="123.065pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M614 175C564 76 510 21 408 21C256 21 146 149 146 336C146 488 235 629 402 629C510 629 570 586 597 480L626 488C620 541 614 582 606 638C578 643 510 665 429 665C206 665 44 527 44 316C44 157 153 -15 402 -15C474 -15 558 5 586 11C604 45 629 119 643 165L614 175Z" id="g190-68"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="665" vert-adv-y="665"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,9.01,0)"><path d="M43 650V622C120 616 128 612 128 526V124C128 39 120 33 34 27V0H270C392 0 492 25 567 83C643 141 690 230 690 350C690 444 655 517 605 565C543 625 450 650 323 650H43ZM213 547C213 587 217 598 226 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International Journal of Cell Biology

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Figure 2

Figure 2: Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer 