Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6

Figure 4

Effect of hydroethanolic extract of Cordia vignei leaves on microscopic changes in the colons of acetic acid-induced colitic rats. Colitis was induced as described in Method. Colons were fixed in 10% formaldehyde, sectioned (5 μm thick), and stained with H&E. Representative photomicrographs shown are colons of naïve control rats (a), acetic acid control rats (b), sulfasalazine-treated rats(c), and 30-300 mg kg^-1 CVE-treated rats (d–f, respectively). Microscopic changes were quantified based on severity of damage (). Results were presented as . (acetic acid control vs. naïve control); ; (acetic acid control vs. treated group).

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