An Efficient Chemoenzymatic Process for Preparation of Ribavirin

Table 1

Optimization of transglycosylation condition.

No.	Nucleoside	Ratio TCA/nucleoside	Time, h	Yield of Ribavirin, %
1	Guo	1 : 1	120	50
2	Guo	1 : 1	360	84
3	Ino	1 : 1	120	45
4	Ino	1 : 1	360	60
5	Guo	1 : 2	120	97
6	Guo	1 : 3	120	97
7	Guo	1 : 5	120	98
8	Guo	1 : 15	120	99