Thermal Hazards of Synthesizing a Grignard Reagent under Different Dosing Rates

Table 2

Thermal parameters for synthesis of Grignard reagent, determined using SIMULAR.

Dosing rate (g⋅min^−1)	Qinduction (kJ)	Qdosing (kJ)	Qtotal (kJ)	ΔrHm (kJ⋅mol^−1)	ΔTad,r (K)
2.0	15.46	134.09	136.85	397.11	204.87
1.0	16.29	128.08	131.77	382.36	191.53
0.5	15.81	123.74	124.99	362.69	177.34

Δ_rH_m is calculated from the reacted moles of p-bromotoluene and yield.